(2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine

Base Information

• Chemical Name: (2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine
• CAS No.: 1352151-64-4
• Molecular Formula: C₁₇H₂₇O₂P
• Molecular Weight: 294.374
• Mol file: 1352151-64-4.mol

Synonyms:(2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine

Chemical Property of (2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine

There total 2 articles about (2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-(2-bromophenyl)-1,3-dioxolan (34824-58-3) + di(tert-butyl)chlorophosphine (13716-10-4) → (2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine (1352151-64-4)

Guidance literature:

2-(2-bromophenyl)-1,3-dioxolan; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h; Inert atmosphere;

di(tert-butyl)chlorophosphine; In tetrahydrofuran; pentane; at -78 ℃; for 16h; Reflux;

DOI:10.1021/ol202977j

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → (2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine (1352151-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid; trimethyl orthoformate / 4 h / 70 °C

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

2.2: 16 h / -78 °C / Reflux

With tert.-butyl lithium; toluene-4-sulfonic acid; trimethyl orthoformate; In tetrahydrofuran; pentane;

DOI:10.1021/ol202977j

Reference yield:

(2-[1,3]dioxolan-2-yl-phenyl)-di-o-tert-butylphosphine (1352151-64-4) → 2-[bis(tert-butyl)phosphino]benzaldehyde (1159683-75-6)

Guidance literature:

With toluene-4-sulfonic acid; In water; acetone; for 24h; Reflux;

DOI:10.1021/ol202977j

upstream raw materials:

2-(2-bromophenyl)-1,3-dioxolan

di(tert-butyl)chlorophosphine

ortho-bromobenzaldehyde

Downstream raw materials:

(3R,9aS)-2-phenyl-3-[2-(di(tert-butyl)phosphino)phenyl]-2,3,9,9a-tetrahydro-1H-imidazo[1,5-a]indole-1-one

2-[bis(tert-butyl)phosphino]benzaldehyde