2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

Base Information

Chemical Name:2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one
CAS No.:1371592-21-0
Molecular Formula:C₃₀H₂₃NO₂
Molecular Weight:429.518
Hs Code.:

Synonyms:2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

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Chemical Property of 2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

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Technology Process of 2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

There total 13 articles about 2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2398-37-0
3-methoxyphenyl bromide

: 1371591-94-4
1-(2-(1-benzyl-4-bromoindol-3-yl)phenyl)ethanone

: 1371592-21-0
2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

Guidance literature:: With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; In 1,4-dioxane; at 60 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo300052z

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 1371591-98-8
2-benzyl-2,6-dihydro-2-aza-dibenzo[cd,h]azulen-7-one

: 1371592-21-0
2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

Guidance literature:: With sodium t-butanolate; In 1,4-dioxane; at 60 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo300052z

Reference yield:

: 100-39-0
benzyl bromide

: 1371592-21-0
2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 45 °C / Inert atmosphere

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 6 h / 80 °C / Inert atmosphere

4.1: chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate / 1,4-dioxane / 2 h / 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium hydride; sodium carbonate; sodium t-butanolate; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo300052z