(S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

Base Information

Chemical Name:(S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide
CAS No.:1429053-30-4
Molecular Formula:C₂₄H₂₇F₄NO₄
Molecular Weight:469.476
Hs Code.:

Synonyms:(S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

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Chemical Property of (S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

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Technology Process of (S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

There total 5 articles about (S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1429053-29-1
2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
(S)-1-(4-methoxyphenyl)ethylamine

: 1429053-30-4
(S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

Guidance literature:: With carbon monoxide; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 20h; under 12929 Torr;
DOI:10.1021/jo400079z

Reference yield:

: 1198785-51-1
3-(2-bromo-4-fluorophenyl)-3-methylbutanoic acid

: 1429053-30-4
(S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / toluene / 12 h / 60 - 65 °C / Large scale

1.2: 1 h / 50 °C / Large scale

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; carbon monoxide / toluene / 20 h / 110 °C / 12929 Torr

With pyridine; carbon monoxide; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400079z

Reference yield:

: 2231-66-5
2,2-dimethyl-5-(propan-2-ylidene)-1,3-dioxane-4,6-dione

: 1429053-30-4
(S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(2-methyl-1-(2-(trifluoromethyl)-1,3-dioxolan-2-yl)propan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -20 - -15 °C / Large scale

1.2: 2 h / 0 - 10 °C / Large scale

2.1: hydrogenchloride / N,N-dimethyl-formamide; water / 15 h / 100 °C / Large scale

3.1: pyridine / toluene / 12 h / 60 - 65 °C / Large scale

3.2: 1 h / 50 °C / Large scale

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; carbon monoxide / toluene / 20 h / 110 °C / 12929 Torr

With pyridine; hydrogenchloride; carbon monoxide; isopropylmagnesium chloride; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400079z