2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

Base Information

Chemical Name:2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane
CAS No.:1429053-29-1
Molecular Formula:C₁₄H₁₅BrF₄O₂
Molecular Weight:371.17
Hs Code.:

Synonyms:2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

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Technology Process of 2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

There total 4 articles about 2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1198785-52-2
4-(2-bromo-4-fluorophenyl)-1,1,1-trifluoro-4-methylpentan-2-one

: 107-07-3
2-chloro-ethanol

: 1429053-29-1
2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo400079z

Reference yield:

: 2231-66-5
2,2-dimethyl-5-(propan-2-ylidene)-1,3-dioxane-4,6-dione

: 1429053-29-1
2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -20 - -15 °C / Large scale

1.2: 2 h / 0 - 10 °C / Large scale

2.1: hydrogenchloride / N,N-dimethyl-formamide; water / 15 h / 100 °C / Large scale

3.1: pyridine / toluene / 12 h / 60 - 65 °C / Large scale

3.2: 1 h / 50 °C / Large scale

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogenchloride; isopropylmagnesium chloride; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400079z

Reference yield:

: 1429053-34-8
5-(2-(2-bromo-4-fluorophenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1429053-29-1
2-(2-(2-bromo-4-fluorophenyl)-2-methylpropyl)-2-(trifluoromethyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / N,N-dimethyl-formamide; water / 15 h / 100 °C / Large scale

2.1: pyridine / toluene / 12 h / 60 - 65 °C / Large scale

2.2: 1 h / 50 °C / Large scale

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400079z