ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

Base Information

Chemical Name:ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate
CAS No.:1373543-44-2
Molecular Formula:C₂₀H₂₁NO₆S
Molecular Weight:403.456
Hs Code.:

Synonyms:ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

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Chemical Property of ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

Chemical Property:

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Technology Process of ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

There total 2 articles about ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373543-42-0
ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

: 1373543-44-2
ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

Guidance literature:: With thionyl chloride; In chloroform; at 45 ℃; for 0.5h; Inert atmosphere;
DOI:10.1055/s-0031-1289706

Reference yield:

: C₁₂H₁₇NO₅S

: 1373543-44-2
ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol; dichloromethane / 10 h / 0 - 4 °C / Inert atmosphere

2: thionyl chloride / chloroform / 0.5 h / 45 °C / Inert atmosphere

With thionyl chloride; triethylamine; In ethanol; dichloromethane; chloroform;
DOI:10.1055/s-0031-1289706

Reference yield:

: 1373543-44-2
ethyl (4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate

: 73231-34-2
Florfenicol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / tetrahydrofuran; ethanol / 1 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; calcium chloride / ethanol / 5 h / 0 - 20 °C / Inert atmosphere

3.1: hexafluoropropene-diethylamine adduct / dichloromethane / 3 h / 100 °C / Inert atmosphere; sealed tube

4.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 45 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / Inert atmosphere

5.2: Inert atmosphere; Heating

6.1: triethylamine / ethanol; dichloromethane / 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; hexafluoropropene-diethylamine adduct; water; sodium ethanolate; sodium hydrogencarbonate; triethylamine; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-0031-1289706