ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

Base Information

Chemical Name:ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate
CAS No.:1373543-42-0
Molecular Formula:C₂₀H₂₃NO₇S
Molecular Weight:421.471
Hs Code.:

Synonyms:ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

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Chemical Property of ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

Chemical Property:

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Technology Process of ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

There total 1 articles about ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₇NO₅S

: 100-07-2
4-methoxy-benzoyl chloride

: 1373543-42-0
ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

: 1373543-41-9
ethyl (2S,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

Guidance literature:: With triethylamine; In ethanol; dichloromethane; at 0 - 4 ℃; for 10h; Inert atmosphere;
DOI:10.1055/s-0031-1289706

Reference yield:

: 1373543-42-0
ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

: 73231-34-2
Florfenicol

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / chloroform / 0.5 h / 45 °C / Inert atmosphere

2.1: sodium ethanolate / tetrahydrofuran; ethanol / 1 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; calcium chloride / ethanol / 5 h / 0 - 20 °C / Inert atmosphere

4.1: hexafluoropropene-diethylamine adduct / dichloromethane / 3 h / 100 °C / Inert atmosphere; sealed tube

5.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 45 °C / Inert atmosphere

6.1: sodium hydrogencarbonate / Inert atmosphere

6.2: Inert atmosphere; Heating

7.1: triethylamine / ethanol; dichloromethane / 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hexafluoropropene-diethylamine adduct; water; sodium ethanolate; sodium hydrogencarbonate; triethylamine; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1055/s-0031-1289706

Reference yield:

: 1373543-42-0
ethyl (2R,3S)-3-hydroxy-2-[(4-methoxybenzoyl)amino]-3-[4-(methylsulfonyl)phenyl]propanoate

: 76639-93-5,105182-37-4,118015-48-8
(1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / chloroform / 0.5 h / 45 °C / Inert atmosphere

2.1: sodium ethanolate / tetrahydrofuran; ethanol / 1 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; calcium chloride / ethanol / 5 h / 0 - 20 °C / Inert atmosphere

4.1: hexafluoropropene-diethylamine adduct / dichloromethane / 3 h / 100 °C / Inert atmosphere; sealed tube

5.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 45 °C / Inert atmosphere

6.1: sodium hydrogencarbonate / Inert atmosphere

6.2: Inert atmosphere; Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hexafluoropropene-diethylamine adduct; water; sodium ethanolate; sodium hydrogencarbonate; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1055/s-0031-1289706