cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Base Information

Chemical Name:cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]
CAS No.:78262-99-4
Molecular Formula:C₂₁H₂₄ClNO
Molecular Weight:341.881
Hs Code.:

Synonyms:cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Suppliers and Price of cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Chemical Property:

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Technology Process of cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

There total 7 articles about cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: cis-3'-(4-chlorophenyl)-4-dimethylamino-3'-hydroxyspiro[cyclohexane-1,1'(3'H)-isobenzofuran]

: 78262-99-4
cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Guidance literature:: With sodium hydroxide; formic acid; In water; toluene;

Reference yield:

: cis-3'-(4-chlorophenyl)-4-dimethylamino-3'-hydroxyspiro[cyclohexane-1,1'-(3'H)-isobenzofuran]

: 78262-99-4
cis-3'-(4-chlorophenyl)-4-dimethylaminospiro[cyclohexane-1,1'(3'H)-isobenzofuran]

Guidance literature:: With sodium hydroxide; formic acid; In water;

Reference yield:

: 93-98-1,5705-51-1
N-phenyl benzoyl amide

: 78262-99-4
[3'-(4-Chloro-phenyl)-3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, a) -40 deg C, 0.75 h, b) 0 deg C, 1 h

2: 9 percent / tetrahydrofuran; benzene; diethyl ether / 1 h / 0 °C

3: 97percent formic acid / 2 h / Heating

With n-butyllithium; formic acid; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jm00137a025