N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

Base Information

Chemical Name:N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine
CAS No.:1206968-68-4
Molecular Formula:C₁₉H₂₄N₄O₄S
Molecular Weight:404.49
Hs Code.:

Synonyms:N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

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Chemical Property of N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

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Technology Process of N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

There total 8 articles about N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1206968-67-3
4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-carbonitrile

: 1206968-68-4
N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

Guidance literature:: With hydroxylamine; In ethanol; at 60 ℃; for 4h;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1206968-68-4
N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 0 - 20 °C

8.1: hydroxylamine / ethanol / 4 h / 60 °C

With hydrogen; hydroxylamine; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1206968-68-4
N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 0 - 20 °C

8.1: hydroxylamine / ethanol / 4 h / 60 °C

With hydrogen; hydroxylamine; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;