5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

Base Information

Chemical Name:5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine
CAS No.:1206967-77-2
Molecular Formula:C₂₃H₂₈N₄O₄S
Molecular Weight:456.566
Hs Code.:

Synonyms:5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

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Chemical Property of 5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

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Technology Process of 5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

There total 9 articles about 5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1206968-68-4
N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine

: 79-31-2
isobutyric Acid

: 1206967-77-2
5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

Guidance literature:: N-Hydroxy-4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidin-1-carboxamidine; isobutyric Acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

In toluene; for 2h; Reflux;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1206967-77-2
5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 0 - 20 °C

8.1: hydroxylamine / ethanol / 4 h / 60 °C

9.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Cooling with ice

9.2: 2 h / Reflux

With hydrogen; hydroxylamine; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1206967-77-2
5-[1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl]-2-(4-methanesulfonylphenoxymethyl)pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triethylamine / chloroform / 3 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 0 - 20 °C

8.1: hydroxylamine / ethanol / 4 h / 60 °C

9.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Cooling with ice

9.2: 2 h / Reflux

With hydrogen; hydroxylamine; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;