(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

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Chemical Name:(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine
CAS No.:1415306-72-7
Molecular Formula:C₂₅H₂₆Cl₂N₂
Molecular Weight:425.401
Hs Code.:

Synonyms:(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

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Chemical Property of (rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

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Technology Process of (rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

There total 5 articles about (rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1415306-71-6
N,N-dibenzyl-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)-propan-1-amine

: 1415306-72-7
(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

Guidance literature:: N,N-dibenzyl-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)-propan-1-amine; With n-butyllithium; potassium tert-butylate; In diethyl ether; hexane; at -75 ℃; for 1h; Inert atmosphere;

With hexachloroethane; In diethyl ether; hexane; at -75 ℃; for 1h; Inert atmosphere;

Reference yield:

: 2396-63-6
hepta-1,6-diyne

: 1415306-72-7
(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,2-dichloro-ethane / 20.5 h / 0 - 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 60 °C / Inert atmosphere

2.2: 3 h / 20 - 70 °C

2.3: 0 °C / pH > 11

3.1: triethylamine / hexane; acetonitrile

4.1: n-butyllithium; 2-(N,N-dimethylamino)ethanol / hexane; diethyl ether / 0.5 h / -65 °C / Inert atmosphere

4.2: 0.5 h / -75 °C

5.1: potassium tert-butylate; n-butyllithium / hexane; diethyl ether / 1 h / -75 °C / Inert atmosphere

5.2: 1 h / -75 °C / Inert atmosphere

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; dimethylsulfide borane complex; potassium tert-butylate; triethylamine; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In tetrahydrofuran; diethyl ether; hexane; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1415306-67-0
3-(6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)-propanenitrile

: 1415306-72-7
(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 60 °C / Inert atmosphere

1.2: 3 h / 20 - 70 °C

1.3: 0 °C / pH > 11

2.1: triethylamine / hexane; acetonitrile

3.1: n-butyllithium; 2-(N,N-dimethylamino)ethanol / hexane; diethyl ether / 0.5 h / -65 °C / Inert atmosphere

3.2: 0.5 h / -75 °C

4.1: potassium tert-butylate; n-butyllithium / hexane; diethyl ether / 1 h / -75 °C / Inert atmosphere

4.2: 1 h / -75 °C / Inert atmosphere

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; dimethylsulfide borane complex; potassium tert-butylate; triethylamine; In tetrahydrofuran; diethyl ether; hexane; acetonitrile;