ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

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Chemical Name:ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate
CAS No.:1431427-08-5
Molecular Formula:C₄₂H₄₂ClN₅O₂
Molecular Weight:684.281
Hs Code.:

Synonyms:ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

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Chemical Property of ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

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Technology Process of ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

There total 9 articles about ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1415306-74-9
Ethyl 3-(5-bromo-2’-cyano-3-methyl-2,3’-bipyridine-5’-yl)-propanoate

: 1415306-72-7
(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine

: 1431427-08-5
ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

Guidance literature:: Ethyl 3-(5-bromo-2’-cyano-3-methyl-2,3’-bipyridine-5’-yl)-propanoate; With potassium acetate; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 130 ℃; for 0.533333h; Microwave irradiation; Inert atmosphere; sealed tube;

(rac)-N,N-dibenzyl-3-chloro-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)propan-1-amine; With potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 0.916667h; Microwave irradiation; Inert atmosphere; sealed tube;

Reference yield:

: 1415306-66-9
ethyl 3-[6-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-yl]-propanoate

: 1431427-08-5
ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

2.1: bis(pinacol)diborane; potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 0.53 h / 130 °C / Microwave irradiation; Inert atmosphere; sealed tube

2.2: 0.92 h / 100 °C / Microwave irradiation; Inert atmosphere; sealed tube

With potassium phosphate; potassium acetate; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; triphenylphosphine; XPhos; In 1,4-dioxane; water;

Reference yield:

: 1415306-75-0
ethyl 3-(6-cyanopyridine-3-yl)propanoate

: 1431427-08-5
ethyl 3-(5-(1-chloro-3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-1-yl)-2'-cyano-3-methyl-2,3'-bipyridin-5'-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere

1.2: 1 h / -75 °C / Inert atmosphere

1.3: 2 h / -75 - 40 °C

2.1: potassium phosphate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

3.1: bis(pinacol)diborane; potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 0.53 h / 130 °C / Microwave irradiation; Inert atmosphere; sealed tube

3.2: 0.92 h / 100 °C / Microwave irradiation; Inert atmosphere; sealed tube

With 2,2,6,6-tetramethyl-piperidine; potassium phosphate; n-butyllithium; potassium acetate; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; triphenylphosphine; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; water;