methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

Base Information

Chemical Name:methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate
CAS No.:239108-91-9
Molecular Formula:C₃₁H₃₁N₃O₆
Molecular Weight:541.604
Hs Code.:

Synonyms:methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

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Chemical Property of methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

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Technology Process of methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

There total 2 articles about methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1912-33-0
Indole-3-acetic acid methyl ester

: 158611-38-2
2-(1-Ethyl-5-methoxy-2-(4-methoxyphenyl)-indol-3-yl)-nitroethen

: 239108-91-9
methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo9825106

Reference yield:

: 5883-83-0
5-methoxy-2-(4-methoxyphenyl)-1H-indole

: 239108-91-9
methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

Guidance literature:: Multi-step reaction with 3 steps

2: NH₄OAc / 4 h / Heating

3: 60 percent / LDA / tetrahydrofuran / -78 - 20 °C

With ammonium acetate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo9825106

Reference yield:

: 239108-91-9
methyl 3-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-2-(1H-3-indolyl)-4-nitrobutanoate

: 4-(1-ethyl-5-methoxy-2-(4-methoxyphenyl)-1H-3-indolyl)-3-(1H-3-indolyl)-2-pyrrolidinone

Guidance literature:: With hydrogen; nickel; sodium hydride; Yield given; Multistep reaction; 1,) Et₂O, EtOH, 12 bar, 48 h, 2.) TolH, reflux, 2 d;
DOI:10.1021/jo9825106