5883-83-0

Basic information

• Product Name: 1H-Indole, 5-methoxy-2-(4-methoxyphenyl)-
• Synonyms: 5-Methoxy-2-(4-methoxyphenyl)-indol;5-methoxy-2-(4-methoxyphenyl)-1H-indole;5-methoxy 2-(4-methoxyphenyl)indole;5-methoxy-2-(4-methoxy-phenyl)-indole;2-(4-methoxyphenyl)-5-methoxy-indole;5-Methoxy-2-(4-methoxy-phenyl)-indol
• CAS NO: 5883-83-0
• Molecular Formula: C16H15NO2
• Molecular Weight: 253.301
• Mol File: 5883-83-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 5-methoxy-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 5-methoxy-2-(4-methoxyphenyl)-(5883-83-0)
• EPA Substance Registry System: 1H-Indole, 5-methoxy-2-(4-methoxyphenyl)-(5883-83-0)

Safety Data

• Hazardous Substances Data: 5883-83-0(Hazardous Substances Data)

Usage

Structure

A derivative of indole with methoxy substituents on the 5 and 2 positions and a 4-methoxyphenyl substituent at the 2 position

Usage

Commonly used in pharmaceutical research and drug development, particularly in the study of serotonin receptors and neurotransmitter systems

Potential pharmacological properties

May be of interest in the development of new drug compounds for various disorders, including psychiatric conditions and neurological diseases

Applications

May have applications in the field of medicinal chemistry and as a starting material for the synthesis of biologically active molecules.

Upstream product

• 263717-54-0 1-(4'-methoxyphenyl)-2-(1''-(4'''-methoxyphenyl)ethylidene)hydrazine 
• 104-94-9 4-methoxy-aniline 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 121-98-2 methyl 4-methoxybenzoate 
• 117616-04-3 4-methoxy-2-trimethylsilylmethylbenzanilide 
• 24876-04-8 1-(2-bromo-4-methoxy-phenyl)-propan-1-one 
• 150-78-7 1,4-dimethoxybezene 
• 1190709-10-4 C₂₂H₁₉NO₄S 
• 6325-62-8 N,1-bis(4-methoxyphenyl)ethan-1-imine 
• 100-66-3 methoxybenzene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1330681-27-0 (4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate 
• 10242-01-0 5-Methoxyindole-3-carboxylic acid 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 115119-02-3 1-(4-Bromo-butyl)-5-methoxy-2-(4-methoxy-phenyl)-1H-indole 
• 91444-30-3 1-Ethyl-5-methoxy-2-(4-methoxyphenyl)-indol 
• 91444-37-0 1,3-Diethyl-5-methoxy-2-(4-methoxy-phenyl)-1H-indole 
• 91444-31-4 5-Methoxy-2-(4-methoxyphenyl)-1-propylindol 
• 91444-38-1 5-Methoxy-2-(4-methoxy-phenyl)-1,3-dipropyl-1H-indole 
• 91444-29-0 5-methoxy-2-(4-methoxyphenyl)-1-methyl-1H-indole 
• 62613-59-6 2-(4'-hydroxy-phenyl)-5-hydroxy-indole 
• 157977-22-5 1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol-3-carbaldehyd 
• 157977-26-9 1-Ethyl-5-methoxy-2-(4-methoxyphenyl)-indol-3-carbaldehyd 
• 157977-24-7 2-(1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan 
• 93316-36-0 5-methoxy-2-(4-methoxyphenyl)-1H-indole-3-carbaldehyde 
• 1519005-49-2 (2E)-3-[5-methoxy-2-(4-methoxyphenyl)-1H-indol-3-yl]-2-(phenylsulfonyl)acrylonitrile 
• 957059-50-6 {[5-methoxy-2-(4-methoxyphenyl)-1H-indol-3-yl]methylene}malononitrile 
• 1519005-66-3 C₁₉H₂₁N₂O₂⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

Regioselective mercury(I)/palladium(II)-catalyzed single-step approach for the synthesis of imines and 2-substituted indoles

An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cycliza-tion of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H acti-vation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.

Preparing method of bazedoxifene derivative

The invention discloses a synthesis method of a bazedoxifene derivative. According to the preparing method of the bazedoxifene derivative, p-anisidine is adopted as a raw material, and through a six-step reaction, the synthesis of the bazedoxifene derivat

Access to 2-Arylindoles via Decarboxylative C?C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base-Free Conditions using Diaryliodonium Salts

Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2-arylindoles and heteroaryl carboxylates in a regioselective fashion. C2-arylated indoles were produced using a Pd-catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base-free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin-dependent kinase (CDK) inhibitor.