2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide

Base Information

• Chemical Name: 2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide
• CAS No.: 1373521-13-1
• Molecular Formula: C₂₆H₃₆N₄OS
• Molecular Weight: 452.664
• Mol file: 1373521-13-1.mol

Synonyms:2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide

Chemical Property of 2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide

There total 2 articles about 2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Cyclohexyl isocyanide (931-53-3) + 1-amino-2-propene (107-11-9,30551-89-4) + 2-(benzylthio)pyrimidin-4-ol (31167-21-2) + isovaleraldehyde (590-86-3) → 2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-13-1)

Guidance literature:

In methanol; Inert atmosphere; Reflux;

DOI:10.1055/s-0031-1290347

Reference yield:

benzyl chloride (100-44-7) → 2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water / 3 h / Reflux

2: methanol / Inert atmosphere; Reflux

With potassium carbonate; In methanol; water; 2: Ugi-Smiles coupling reaction;

DOI:10.1055/s-0031-1290347

Reference yield: 94.0%

2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-13-1) → 2-(allyl(2-(benzylsulfonyl)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2018.04.058

upstream raw materials:

Cyclohexyl isocyanide

1-amino-2-propene

2-(benzylthio)pyrimidin-4-ol

isovaleraldehyde

Downstream raw materials:

2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide