2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide

Base Information

• Chemical Name: 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide
• CAS No.: 1373521-42-6
• Molecular Formula: C₂₆H₃₆ClN₅O
• Molecular Weight: 470.058
• Mol file: 1373521-42-6.mol

Synonyms:2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide

Chemical Property of 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide

There total 6 articles about 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-13-1) + 4-chlorobenzylamine (104-86-9) → 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-42-6)

Guidance literature:

2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene; at 20 ℃; for 2h; Inert atmosphere;

4-chlorobenzylamine; In dichloromethane; toluene; at 20 - 110 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2018.04.058

Reference yield: 48.0%

Cyclohexyl isocyanide (931-53-3) + 4-chlorobenzylamine (104-86-9) + 1-amino-2-propene (107-11-9,30551-89-4) + 2-(benzylthio)pyrimidin-4-ol (31167-21-2) + isovaleraldehyde (590-86-3) → 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-42-6)

Guidance literature:

Cyclohexyl isocyanide; 1-amino-2-propene; 2-(benzylthio)pyrimidin-4-ol; isovaleraldehyde; In toluene; for 72h; Inert atmosphere; Heating;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene; at 20 ℃; for 5h; Inert atmosphere;

4-chlorobenzylamine; In dichloromethane; toluene; at 20 - 110 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2018.04.058

Reference yield:

2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-13-1) → 2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide (1373521-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; toluene / 2 h / 20 °C / Inert atmosphere

2: dichloromethane; toluene / 7.33 h / 20 - 110 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;

DOI:10.1055/s-0031-1290347

upstream raw materials:

2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-N-cyclohexyl-4-methylpentanamide

4-chlorobenzylamine

Cyclohexyl isocyanide

isovaleraldehyde