N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

Base Information

Chemical Name:N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide
CAS No.:1382488-85-8
Molecular Formula:C₁₉H₁₉ClF₃NO₃S₂
Molecular Weight:465.945
Hs Code.:

Synonyms:N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

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Chemical Property of N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

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Technology Process of N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

There total 4 articles about N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanoic acid

: 119511-41-0
2-((2-chlorophenyl)thio)ethan-1-amine

: 1382488-85-8
N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

Guidance literature:: 2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

2-((2-chlorophenyl)thio)ethan-1-amine; In tetrahydrofuran; at 23 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c00371

Reference yield:

: 6320-03-2
2-chlorothiphenol

: 1382488-85-8
N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium / isopropyl alcohol / 0.5 h / 20 °C

1.2: 6 h / Reflux

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 1 h / 23 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.0c00371

Reference yield:

: 1004769-90-7
2-methyl-2-(4-trifluoromethyl-phenylsulfanyl)-propionic acid ethyl ester

: 1382488-85-8
N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium peroxymonosulfate sulfate / 1,4-dioxane; water / 18 h / 23 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18.5 h / 23 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 1 h / 23 °C / Inert atmosphere

With potassium peroxymonosulfate sulfate; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/acs.jmedchem.0c00371