diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

Base Information

Chemical Name:diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate
CAS No.:852947-24-1
Molecular Formula:C₁₈H₂₁I₃NO₅P
Molecular Weight:743.056
Hs Code.:

Synonyms:diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

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Chemical Property of diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

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Technology Process of diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

There total 11 articles about diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 852947-23-0
diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

: 852947-24-1
diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

Guidance literature:: diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate; With water; trifluoroacetic acid; at 20 ℃; for 1h;

With iodine; methylamine; potassium iodide; In ethanol; water; at 0 ℃; for 1h;

Reference yield:

: C₁₈H₂₂I₂NO₅P

: 852947-24-1
diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

Guidance literature:: With iodine; methylamine; potassium iodide; In ethanol; water; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm800824d

Reference yield:

: 91726-12-4,84891-34-9
diethyl 1-amino-2-(4-benzyloxyphenyl)ethyl phosphonate

: 852947-24-1
diethyl 1-amino-2-[3,5-diiodo-4-(4'-hydroxy-3-iodophenoxy)phenyl]ethylphosphonate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 4 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 16 h

3: [bis(pyridine)iodine]⁺ tetrafluoroborate / dichloromethane / 1 h / 20 °C

4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieves 4A

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

6: water; trifluoroacetic acid / 1 h / 20 °C

7: iodine; methylamine; potassium iodide / ethanol; water / 1 h / 0 °C

With pyridine; tetrabutyl ammonium fluoride; water; hydrogen; iodine; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; methylamine; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; copper diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;