diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

Base Information

Chemical Name:diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate
CAS No.:852947-23-0
Molecular Formula:C₂₃H₃₀I₂NO₇P
Molecular Weight:717.276
Hs Code.:

Synonyms:diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

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Chemical Property of diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

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Technology Process of diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

There total 9 articles about diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 852947-22-9
diethyl 1-(tert-butoxycarbonylamino)-2-[4-(4'-(tert-butyldimethylsilyloxy)phenoxy)-3,5-diiodophenyl]ethylphosphonate

: 852947-23-0
diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h;

Reference yield:

: C₁₇H₂₈NO₆P

: 852947-23-0
diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: [bis(pyridine)iodine]⁺ tetrafluoroborate / dichloromethane / 1 h / 20 °C

2: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieves 4A

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

With pyridine; tetrabutyl ammonium fluoride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; copper diacetate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 91726-12-4,84891-34-9
diethyl 1-amino-2-(4-benzyloxyphenyl)ethyl phosphonate

: 852947-23-0
diethyl 1-tert-butoxycarbonylamino-2-[4-(4'-hydroxyphenoxy)-3,5-diiodophenyl]ethylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 4 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 16 h

3: [bis(pyridine)iodine]⁺ tetrafluoroborate / dichloromethane / 1 h / 20 °C

4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieves 4A

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

With pyridine; tetrabutyl ammonium fluoride; hydrogen; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; palladium 10% on activated carbon; copper diacetate; In tetrahydrofuran; methanol; dichloromethane;