phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

Base Information

Chemical Name:phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate
CAS No.:134848-83-2
Molecular Formula:C₃₂H₄₉N₅O₈
Molecular Weight:631.77
Hs Code.:

phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

Synonyms:phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

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Chemical Property of phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

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Technology Process of phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

There total 5 articles about phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 134848-99-0
(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

: 134848-83-2
phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

Guidance literature:: With 1-Hydrobenzotriazole monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Yield given;
DOI:10.1021/jm00113a005

Reference yield:

: 134848-81-0
(4S,5R)-4-(cyclohexylmethyl)-5-<2-(3-hydroxypropyl)-1,3-dioxolan-2-yl>-2-oxazolidinone

: 134848-83-2
phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: LiN₃ / dimethylformamide / Ambient temperature

3: 992 mg / Ba(OH)2 / dioxane; H₂O / Heating

4: benzotriazole monohydrate (HOBt), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / CH₂Cl₂ / 0 - 20 °C

With barium dihydroxide; lithium azide; 1-Hydrobenzotriazole monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a005

Reference yield:

: 134848-98-9
3-[2-((4S,5R)-4-Cyclohexylmethyl-2-oxo-oxazolidin-5-yl)-[1,3]dioxolan-2-yl]-propionic acid

: 134848-83-2
phenylmethyl (4S)-5-<(1S,2R)-<2-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-1-(cyclohexylmethyl)-2-hydroxyethyl>amino>-4-<<(1,1-dimethylpropyl)carbonyl>amino>-5-oxopentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / BH₃*SMe₂ / tetrahydrofuran / 3 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: LiN₃ / dimethylformamide / Ambient temperature

4: 992 mg / Ba(OH)2 / dioxane; H₂O / Heating

5: benzotriazole monohydrate (HOBt), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / CH₂Cl₂ / 0 - 20 °C

With barium dihydroxide; lithium azide; dimethylsulfide borane complex; 1-Hydrobenzotriazole monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a005