4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

Base Information

Chemical Name:4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide
CAS No.:1318791-96-6
Molecular Formula:BrH*C₁₇H₁₇N₃O₃
Molecular Weight:392.252
Hs Code.:

Synonyms:4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

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Chemical Property of 4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

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Technology Process of 4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

There total 4 articles about 4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1318791-92-2
allyl-4-[6-Imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

: 1318791-96-6
4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 19 - 22 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.067

Reference yield:

: 1227266-47-8
4-(6-amino-pyridazin-3-yl)-phenol

: 1318791-96-6
4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.67 h / 19 - 22 °C / Inert atmosphere

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Williamson ether synthesis / 1.2: Williamson ether synthesis;
DOI:10.1016/j.bmcl.2011.05.067

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1318791-96-6
4-[6-imino-3-(4-prop-2-ynyloxy-phenyl)-6H-pyridazin-1-yl]-butyric acid hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / acetonitrile / 0.17 h / 120 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.67 h / 19 - 22 °C / Inert atmosphere

With morpholine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2.1: Williamson ether synthesis / 2.2: Williamson ether synthesis;
DOI:10.1016/j.bmcl.2011.05.067