2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine

Base Information

• Chemical Name: 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine
• CAS No.: 1234572-54-3
• Molecular Formula: C₁₇H₁₄FN₇O
• Molecular Weight: 351.343
• Mol file: 1234572-54-3.mol

Synonyms:2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine

Chemical Property of 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine

There total 7 articles about 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]-5-nitropyrimidine-4,6-diamine (1234572-86-1) → 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine (1234572-54-3)

Guidance literature:

With pyridine; hydrogen; palladium 10% on activated carbon; for 7h; under 2250.23 Torr;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine (1234572-54-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 4 h / 20 °C

2.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide; ethanol / 1 h / Reflux

3.1: hydrogenchloride; tert.-butylnitrite / N,N-dimethyl-formamide / 50 °C

4.1: trifluoroacetic acid / 1 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

6.1: hydrogen; pyridine / palladium 10% on activated carbon / 7 h / 2250.23 Torr

With pyridine; hydrogenchloride; tert.-butylnitrite; tin(II) chloride dihdyrate; hydrogen; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

3-(2-Fluorophenoxy)-1-(4-methoxybenzyl)-1H-indazole (1234572-84-9) → 2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine (1234572-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1 h / 70 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3: hydrogen; pyridine / palladium 10% on activated carbon / 7 h / 2250.23 Torr

With pyridine; hydrogen; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

3,4-difluoronitrobenzene

3-(2-Fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-indazole

1-(p-methoxybenzyl)-1H-indazol-3-ol

3-Fluoro-4-{[1-(4-methoxybenzyl)-1H-indazol-3-yl]oxy}aniline

Downstream raw materials:

propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Refernces