propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Base Information

• Chemical Name: propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate
• CAS No.: 1234572-66-7
• Molecular Formula: C₂₁H₂₀FN₇O₃
• Molecular Weight: 437.433
• Mol file: 1234572-66-7.mol

Synonyms:propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Chemical Property of propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

There total 8 articles about propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine (1234572-54-3) + isopropyl chloroformate (108-23-6) → propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate (1234572-66-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate (1234572-66-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 4 h / 20 °C

2.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide; ethanol / 1 h / Reflux

3.1: hydrogenchloride; tert.-butylnitrite / N,N-dimethyl-formamide / 50 °C

4.1: trifluoroacetic acid / 1 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

6.1: hydrogen; pyridine / palladium 10% on activated carbon / 7 h / 2250.23 Torr

7.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

With pyridine; hydrogenchloride; tert.-butylnitrite; tin(II) chloride dihdyrate; hydrogen; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

3-(2-Fluorophenoxy)-1-(4-methoxybenzyl)-1H-indazole (1234572-84-9) → propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate (1234572-66-7)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / 1 h / 70 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3: hydrogen; pyridine / palladium 10% on activated carbon / 7 h / 2250.23 Torr

4: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

With pyridine; hydrogen; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine

isopropyl chloroformate

3,4-difluoronitrobenzene

3-(2-Fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-indazole

Refernces