propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Base Information

Chemical Name:propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate
CAS No.:1234572-66-7
Molecular Formula:C₂₁H₂₀FN₇O₃
Molecular Weight:437.433
Hs Code.:

Synonyms:propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

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Chemical Property of propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

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Technology Process of propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

There total 8 articles about propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1234572-54-3
2-[3-(2-Fluorophenoxy)-1H-indazol-1-yl]pyrimidine-4,5,6-triamine

: 108-23-6
isopropyl chloroformate

: 1234572-66-7
propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1234572-66-7
propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 4 h / 20 °C

2.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide; ethanol / 1 h / Reflux

3.1: hydrogenchloride; tert.-butylnitrite / N,N-dimethyl-formamide / 50 °C

4.1: trifluoroacetic acid / 1 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

6.1: hydrogen; pyridine / palladium 10% on activated carbon / 7 h / 2250.23 Torr

7.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

With pyridine; hydrogenchloride; tert.-butylnitrite; tin(II) chloride dihdyrate; hydrogen; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1234572-84-9
3-(2-Fluorophenoxy)-1-(4-methoxybenzyl)-1H-indazole

: 1234572-66-7
propan-2-yl {4,6-diamino-2-[3-(2-fluorophenoxy)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 1 h / 70 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3: hydrogen; pyridine / palladium 10% on activated carbon / 7 h / 2250.23 Torr

4: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

With pyridine; hydrogen; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In dichloromethane; N,N-dimethyl-formamide; mineral oil;