dimethyl [2-(4-methoxyphenyl)ethyl]malonate

Base Information

• Chemical Name: dimethyl [2-(4-methoxyphenyl)ethyl]malonate
• CAS No.: 1027664-82-9
• Molecular Formula: C₁₄H₁₈O₅
• Molecular Weight: 266.294
• Mol file: 1027664-82-9.mol

Synonyms:dimethyl [2-(4-methoxyphenyl)ethyl]malonate

Chemical Property of dimethyl [2-(4-methoxyphenyl)ethyl]malonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl [2-(4-methoxyphenyl)ethyl]malonate

There total 4 articles about dimethyl [2-(4-methoxyphenyl)ethyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

dimethyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate (75073-97-1) → dimethyl [2-(4-methoxyphenyl)ethyl]malonate (1027664-82-9)

Guidance literature:

With acetic acid; zinc; In methanol; for 0.0833333h; Reflux;

DOI:10.1021/acs.joc.7b01549

Reference yield: 28.0%

4-Methoxystyrene (637-69-4,24936-44-5) + malonic acid dimethyl ester (108-59-8) → dimethyl [2-(4-methoxyphenyl)ethyl]malonate (1027664-82-9)

Guidance literature:

With 3,5-difluoro-2,4,6-tris(N-phenylanilino)benzonitrile; potassium tert-butylate; In acetonitrile; at 20 ℃; for 20h; Irradiation; Inert atmosphere;

DOI:10.1021/acscatal.0c02716

Reference yield:

1-iodo-2-(4-methoxyphenyl)ethane (38954-00-6) + malonic acid dimethyl ester (108-59-8) → dimethyl [2-(4-methoxyphenyl)ethyl]malonate (1027664-82-9)

Guidance literature:

malonic acid dimethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

1-iodo-2-(4-methoxyphenyl)ethane; With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 0 - 70 ℃; for 4h;

DOI:10.1002/ejoc.201201387

upstream raw materials:

1-iodo-2-(4-methoxyphenyl)ethane

malonic acid dimethyl ester

dimethyl 2-(4-methoxybenzylidene)malonate

dimethyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate

Refernces

• 1、 Ivanov, Konstantin L.,Villemson, Elena V.,Latyshev, Gennadij V.,Bezzubov, Stanislav I.,Majouga, Alexander G.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.. "Regioselective Hydrogenolysis of Donor-Acceptor Cyclopropanes with Zn-AcOH Reductive System". . p. 9537 - 9549. Retrieved 2017/09/23.