(5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone

Base Information

Chemical Name:(5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone
CAS No.:1027172-71-9
Molecular Formula:C₁₆H₂₁NO₂
Molecular Weight:259.348
Hs Code.:

Synonyms:(5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone

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Chemical Property of (5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone

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Technology Process of (5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone

There total 18 articles about (5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1312994-84-5
(5S)-6-(((S)-1,2,3,5,6,8a-hexahydroindolizin-8-yl)(hydroxy)methyl)-5-methylcyclohex-2-enone

: 1027172-71-9
(5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone

Guidance literature:: (5S)-6-(((S)-1,2,3,5,6,8a-hexahydroindolizin-8-yl)(hydroxy)methyl)-5-methylcyclohex-2-enone; With dimethyl sulfoxide; trifluoroacetic anhydride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol2014939

Reference yield: 63.0%

: 1127424-80-9
(8aS,2'R,3'S,5'S)-(3-methyl-5-phenylsulfanyl)-2'-(3-thioxo-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)cyclohexanone

: 1027172-71-9
(5S)-6-((S)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)-5-methylcyclohex-2-enone

Guidance literature:: (8aS,2'R,3'S,5'S)-(3-methyl-5-phenylsulfanyl)-2'-(3-thioxo-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl)cyclohexanone; With trimethoxonium tetrafluoroborate; In acetonitrile; at 20 ℃; for 1h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;
DOI:10.1021/ol900032h