N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

Base Information

Chemical Name:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide
CAS No.:88084-40-6
Molecular Formula:C₃₀H₄₂N₄O₆
Molecular Weight:554.687
Hs Code.:

Synonyms:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

Suppliers and Price of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

Chemical Property:

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Technology Process of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

There total 8 articles about N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86787-33-9
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

: 88084-40-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 3h; under 3102.9 Torr;
DOI:10.1021/jm00369a017

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 88084-40-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

2: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

3: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

4: 66 percent / 2.5 N NaOH / methanol / 25 °C

5: 63 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 48 h / 25 °C / pH 7.0-7.5

6: H₂, AcOH / 10percent Pd/C / ethanol / 3 h / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; palladium on carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 88084-40-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-aminopropylamide

Guidance literature:: Multi-step reaction with 7 steps

1: 48percent HBr / acetic acid / Heating

2: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

3: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

4: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

5: 66 percent / 2.5 N NaOH / methanol / 25 °C

6: 63 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 48 h / 25 °C / pH 7.0-7.5

7: H₂, AcOH / 10percent Pd/C / ethanol / 3 h / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen bromide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; palladium on carbon; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017