4-Hydroxybenzenebutyric acid methyl ester

Base Information

• Chemical Name: 4-Hydroxybenzenebutyric acid methyl ester
• CAS No.: 22320-10-1
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2918290000
• Mol file: 22320-10-1.mol

Synonyms:Butyricacid, 4-(p-hydroxyphenyl)-, methyl ester (8CI); 4-(p-Hydroxyphenyl)butyric acidmethyl ester; Methyl 4-(4-hydroxyphenyl)butanoate; Methyl4-(4-hydroxyphenyl)butyrate

Chemical Property of 4-Hydroxybenzenebutyric acid methyl ester

Chemical Property:

• Vapor Pressure: 0.000159mmHg at 25°C
• Boiling Point: 321.4°C at 760 mmHg
• Flash Point: 136°C
• PSA: 46.53000
• Density: 1.118g/cm³
• LogP: 1.88790
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

METHYL 4-(4-HYDROXYPHENYL)BUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-?Hydroxy-?benzenebutanoic Acid Methyl Ester is an intermediate in synthesizing Arbutamine (A766300). It is a cardiac stimulant. Arbutamine stimulates adrenergic receptors.

Technology Process of 4-Hydroxybenzenebutyric acid methyl ester

There total 5 articles about 4-Hydroxybenzenebutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(4-methoxyphenyl)butyric acid methyl ester (20637-08-5) → methyl 4-(4-hydroxyphenyl)butanoate (22320-10-1)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield: 97.0%

methanol (67-56-1) + 4-(4-hydroxyphenyl)butanoic acid (7021-11-6) → methyl 4-(4-hydroxyphenyl)butanoate (22320-10-1)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.1016/j.bmc.2005.04.011

Reference yield:

4-(4-hydroxyphenyl)butanoic acid (7021-11-6) + methyl iodide (74-88-4) → methyl 4-(4-hydroxyphenyl)butanoate (22320-10-1)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

upstream raw materials:

methanol

4-(4-hydroxyphenyl)butanoic acid

4-(4-methoxyphenyl)butyric acid methyl ester

methyl iodide

Downstream raw materials:

4-(p-Isopropyloxy-phenyl)-buttersaeure

4--buttersaeure

4--buttersaeure

4-<4-(2.4-Dinitro-phenoxy)-phenyl>-buttersaeure