potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

Base Information

Chemical Name:potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate
CAS No.:1354627-07-8
Molecular Formula:C₁₈H₁₈NO₅*K
Molecular Weight:367.443
Hs Code.:

Synonyms:potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

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Chemical Property of potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

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Technology Process of potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

There total 4 articles about potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1354627-12-5
(4S,5R,6S)-3-(4-acetyl-phenyl)-4-methyl-7-oxo-6-((1'R)-hydroxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester

: 1354627-07-8
potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃; for 0.333333h;

Reference yield:

: 1354627-11-4
(4S,5R,6S)-3-(4-acetyl-phenyl)-4-methyl-7-oxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester

: 1354627-07-8
potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

2: palladium 10% on activated carbon; potassium hydrogencarbonate; hydrogen / tetrahydrofuran; water / 0.33 h / 0 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; potassium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 186817-91-4
(4R,5R,6S)-4-methyl-3,7-dioxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl-ester

: 1354627-07-8
potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / dichloromethane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

4.1: palladium 10% on activated carbon; potassium hydrogencarbonate; hydrogen / tetrahydrofuran; water / 0.33 h / 0 °C

With hydrogenchloride; potassium phosphate; palladium 10% on activated carbon; water; hydrogen; potassium hydrogencarbonate; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water;