186817-91-4

Upstream product

• 186817-88-9 (R)-2-Diazo-3-oxo-4-[(2R,3S)-4-oxo-3-((R)-1-triethylsilanyloxy-ethyl)-azetidin-2-yl]-pentanoic acid 4-nitro-benzyl ester 
• 994-30-9 triethylsilyl chloride 
• 90822-24-5 (γR,2R,3S)-α-diazo-3-[(1R)-1-hydroxyethyl]-γ-methyl-β,4-dioxo-2-azetidinebutanoic acid (4-nitrophenyl)methyl ester 

Downstream Products

• 165817-82-3 4-nitrobenzyl (1R,5R,6S)-1-methyl-6-[(1R)-triethylsilanyloxy-ethyl]-2-(trifluoro-methanesulfonyloxy)-carbapen-2-em-3-carboxylate 
• 1354627-17-0 (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-acetoxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 1354627-07-8 potassium (4S,5R,6S)-3-(4-acetyl-phenyl)-6-((1′R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 1354627-16-9 (4S,5R,6S)-3-(4'-acetyl-biphenyl-4-yl)-6-((1'R)-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 1354627-15-8 (4S,5R,6S)-3-(4'-acetyl-biphenyl-4-yl)-4-methyl-7-oxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 1354627-14-7 (4S,5R,6S)-6-((1'R)-hydroxyethyl)-4-methyl-3-(4-nitro-phenyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 1354627-13-6 (4S,5R,6S)-4-methyl-3-(4-nitro-phenyl)-7-oxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 1354627-12-5 (4S,5R,6S)-3-(4-acetyl-phenyl)-4-methyl-7-oxo-6-((1'R)-hydroxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 1354627-11-4 (4S,5R,6S)-3-(4-acetyl-phenyl)-4-methyl-7-oxo-6-((1'R)-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl-ester 
• 169957-63-5 [4S-(4α,5β,6β(S*))]-1-(2-amino-2-oxoethyl)-4-({6-[2-carboxy-6-(1-hydroxyethyl)4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]-9-oxo-9H-fluoren-2-yl}methyl)-1,4-diazaniabicyclo[2.2.2]octane chloride 
• 212691-56-0 (4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 169552-95-8 (4S,5R,6S)-4-Methyl-7-oxo-3-(9-oxo-7-trimethylsilanyloxymethyl-9H-fluoren-3-yl)-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 157743-80-1 (4S,5R,6S)-3-(7-Hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof

A process for preparation of a compound of formula I: wherein: R1represents CH3or H; and P represents a protecting group; comprising reacting a compound of formula IV: ?wherein R1and P and are defined above and R4/su

Practical synthesis of anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem L-742,728

Anti-MRSA carbapenem, L-742,728, has been prepared in large quantity using the Suzuki-Miyaura cross-coupling as the key reaction. Three approaches have been examined by varying the coupling reaction between carbapenem nucleus A and side chains B, BC, and