8-methylquinazoline-2,4(1H,3H)-dione

Base Information

• Chemical Name: 8-methylquinazoline-2,4(1H,3H)-dione
• CAS No.: 67449-23-4
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 67449-23-4.mol

Synonyms:2,4-Quinazolinediol,8-methyl- (6CI);2,4-Dihydroxy-8-methylquinazoline;8-Methyl-1,2,3,4-tetrahydro-2,4-quinazolinedione;NSC 338216;y-Thymine-m;yT-m;yT-methyl;

Chemical Property of 8-methylquinazoline-2,4(1H,3H)-dione

Chemical Property:

• Vapor Pressure: 4.87E-10mmHg at 25°C
• Melting Point: 283 °C
• Refractive Index: 1.576
• Boiling Point: 485.2 °C at 760 mmHg
• PKA: 11.13±0.20(Predicted)
• Flash Point: 247.2 °C
• PSA: 65.72000
• Density: 1.28 g/cm³
• LogP: 0.52480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-methylquinazoline-2,4(1H,3H)-dione

There total 11 articles about 8-methylquinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

methyl (3-methyl-2-nitrobenzoyl)carbamate → 8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (67449-23-4)

Guidance literature:

With palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; In methanol; at 20 ℃; for 3h;

DOI:10.1080/00397911.2018.1439173

Reference yield: 82.0%

potassium cyanate (590-28-3) + 3-methylantranilic acid (4389-45-1) → 8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (67449-23-4)

Guidance literature:

With acetic acid; In polyethyleneglycol (PEG-400); at 20 - 60 ℃; for 0.166667h;

DOI:10.1016/j.cclet.2012.01.027

Reference yield: 77.0%

3-methylantranilic acid (4389-45-1) + urea (57-13-6) → 8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (67449-23-4)

Guidance literature:

3-methylantranilic acid; urea; at 160 ℃; for 6h;

With water; at 100 ℃; for 0.0833333h;

DOI:10.1016/j.bmcl.2011.10.104

upstream raw materials:

potassium cyanate

3-methylantranilic acid

8-methyl-N²,N⁴-di-o-tolyl-quinazoline-2,4-diyldiamine

urea

Downstream raw materials:

2,4,-dichloro-8-methylquinazoline

2-chloro-8-methyl-4-(2-methylphenylamino)quinazoline

2-chloro-8-methylquinazolin-4(3H)-one