(R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile

Base Information

• Chemical Name: (R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile
• CAS No.: 871558-47-3
• Molecular Formula: C₁₆H₂₂N₂O₂
• Molecular Weight: 274.363
• Mol file: 871558-47-3.mol

Synonyms:(R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile

Chemical Property of (R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile

There total 1 articles about (R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine + trimethylsilyl cyanide (7677-24-9) → (R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile (871558-47-3)

Guidance literature:

In dichloromethane; at -20 ℃; for 6h;

DOI:10.1021/jo051592c

Reference yield:

(R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile (871558-47-3) → (R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-N2-((S)-1-phenyl-ethyl)-propane-1,2-diamine

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo051592c

Reference yield:

(R)-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanenitrile (871558-47-3) → (R)-N-acetyl-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-propylamine (871558-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 3 h / 0 - 20 °C

2: 3.82 g / triethylamine; DMAP / CH₂Cl₂ / 2 h / 20 °C

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo051592c

upstream raw materials:

trimethylsilyl cyanide

Downstream raw materials:

(R)-N-acetyl-2-[(S)-1-phenylethylamino]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-propylamine