(1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

Base Information

Chemical Name:(1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane
CAS No.:474023-03-5
Molecular Formula:C₂₂H₃₆O₄SSi
Molecular Weight:424.677
Hs Code.:

Synonyms:(1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

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Chemical Property of (1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

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Technology Process of (1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

There total 6 articles about (1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 474023-27-3
(1R,4S,5S)-3-benzenesulfonyl-5-(tert-butyldimethylsilanyloxy)-4-isopropylcyclohex-2-enol

: 74-88-4
methyl iodide

: 474023-03-5
(1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 25 ℃; for 0.166667h;
DOI:10.1021/ja026760m

Reference yield: 98.0%

: 474023-03-5
(1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

Guidance literature:

Reference yield:

: 474022-99-6
(1S,5S,6S)-5-benzenesulfonyl-6-isopropylcyclohex-3-enol

: 474023-03-5
(1S,2S,5R)-(3-benzenesulfonyl-2-isopropyl-5-methoxycyclohex-3-enyloxy)-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / tert-butyl hydrogenperoxide; Mo(CO)6 / benzene / 1.5 h / Heating

2: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

3: 99 percent / DBU / tetrahydrofuran / 1 h / Heating

4: 98 percent / KOH / dimethylsulfoxide / 0.17 h / 25 °C

With tert.-butylhydroperoxide; potassium hydroxide; hexacarbonyl molybdenum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1021/ja026760m