methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Base Information

Chemical Name:methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate
CAS No.:1458652-80-6
Molecular Formula:C₃₃H₃₇FO₆
Molecular Weight:548.652
Hs Code.:

Synonyms:methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

There total 10 articles about methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1458652-59-9
methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1458652-81-7
3-(4-bromo-3,5-dimethylphenoxy)-2,2-dimethylpropan-1-ol

: 1458652-80-6
methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1458652-82-8
methyl 2-((S)-6-((R)-4-(4-(2,2-dimethyl-3-oxopropoxy)-2,6-dimethylphenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; toluene; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1003-85-6
5.5-dimethyl-1,3,2-dioxathiane-2-oxide

: 1458652-80-6
methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

2: potassium phosphate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 12 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; caesium carbonate; In water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 1458652-80-6
methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 3 h / 40 °C / Cooling with ice

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

3: potassium phosphate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 12 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; thionyl chloride; palladium diacetate; caesium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;