ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate

Base Information

• Chemical Name: ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate
• CAS No.: 125666-70-8
• Molecular Formula: C₂H₄O₂*C₁₆H₂₅NO₅
• Molecular Weight: 371.431
• Mol file: 125666-70-8.mol

Synonyms:ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate

Chemical Property of ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate

There total 5 articles about ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

acetic acid (64-19-7,77671-22-8) + Ethyl 5-<4-<(tritylamino)methyl>-3,5-dimethoxyphenoxy>valerate (149286-69-1) → ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate (125666-70-8)

Guidance literature:

With hydrogen; ammonium formate; palladium on activated charcoal; In ethanol; at 25 ℃; for 50h;

DOI:10.1021/jo00070a041

Reference yield:

ethyl 5-(4-hydroximinomethyl-3,5-dimethoxyphenoxy)valerate (125666-68-4) → ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate (125666-70-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 25 ℃; for 2h; under 2280 Torr;

DOI:10.1021/jo00299a011

Reference yield:

ethyl 5'-(4-formyl-3,5-dimethoxyphenoxy)valerate (115109-57-4) → ethyl 5-(4-aminomethyl-3,5-dimethoxyphenoxy)valerate acetate (125666-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) molecular sieves 3A, 2.) NaBH₃CN / 1.) MeOH, reflux, 6 h, 2.) 2 h

2: 70 percent / ammonium formate, H₂ / 10percent Pd/C / ethanol / 50 h / 25 °C

With 3 A molecular sieve; hydrogen; ammonium formate; sodium cyanoborohydride; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00070a041

upstream raw materials:

ethyl 5-(4-hydroximinomethyl-3,5-dimethoxyphenoxy)valerate

acetic acid

Ethyl 5-<4-<(tritylamino)methyl>-3,5-dimethoxyphenoxy>valerate

ethyl 5'-(4-formyl-3,5-dimethoxyphenoxy)valerate

Downstream raw materials:

5-<4-<<(Fmoc)amino>methyl>-3,5-dimethoxyphenoxy>valeric acid