2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

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Chemical Name:2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal
CAS No.:1071835-99-8
Molecular Formula:C₂₀H₂₉N₃O₃
Molecular Weight:359.469
Hs Code.:

Synonyms:2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

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Chemical Property of 2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

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Technology Process of 2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

There total 3 articles about 2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1071835-98-7
2-(4-bromo-1-methylpyrazol-5-yl)acetaldehyde dimethyl acetal

: 1071835-99-8
2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

Guidance literature:: 2-(4-bromo-1-methylpyrazol-5-yl)acetaldehyde dimethyl acetal; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

1-phenylmethyl-4-piperidone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 21.5h;

With water; In tetrahydrofuran; hexane;

Reference yield:

: 1334473-87-8
C₈H₁₄N₂O₂

: 1071835-99-8
2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium hydrobromide perbromide; trimethyl orthoformate / methanol / 19 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: 21.5 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; pyridinium hydrobromide perbromide; trimethyl orthoformate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm200585k

Reference yield:

: 1071835-97-6
5-(2-methoxyvinyl)-1-methylpyrazole

: 1071835-99-8
2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 115 h / Reflux

2.1: pyridinium hydrobromide perbromide; trimethyl orthoformate / methanol / 19 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

3.2: 21.5 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; pyridinium hydrobromide perbromide; toluene-4-sulfonic acid; trimethyl orthoformate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm200585k