1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

Base Information

Chemical Name:1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]
CAS No.:1071835-73-8
Molecular Formula:C₁₉H₂₅N₃O₂
Molecular Weight:327.426
Hs Code.:

Synonyms:1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

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Chemical Property of 1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

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Technology Process of 1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

There total 6 articles about 1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1071835-99-8
2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

: 1071835-73-8
1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

Guidance literature:: 2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal; With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 24h;

With sodium hydroxide; In methanol; water;

Reference yield: 41.0%

: 67-56-1
methanol

: 1071835-99-8
2-[4-(1-benzyl-4-hydroxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

: 1071835-73-8
1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

: 1334473-93-6
2-[4-(1-benzyl-4-methoxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

Guidance literature:: With toluene-4-sulfonic acid; at 20 ℃; for 24h;
DOI:10.1021/jm200585k

Reference yield:

: 1071835-98-7
2-(4-bromo-1-methylpyrazol-5-yl)acetaldehyde dimethyl acetal

: 1071835-73-8
1-benzyl-6'-methoxy-1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

: 1334473-93-6
2-[4-(1-benzyl-4-methoxypiperidin-4-yl)-1-methylpyrazol-5-yl]acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: 21.5 h / -78 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / 24 h / 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane;
DOI:10.1021/jm200585k