5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Base Information

Chemical Name:5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride
CAS No.:1609575-43-0
Molecular Formula:C₂₃H₂₂ClF₆N₃*ClH
Molecular Weight:526.352
Hs Code.:

Synonyms:5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Suppliers and Price of 5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

There total 4 articles about 5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 1609575-43-0
5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Guidance literature:: 4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid; With HATU; In N,N-dimethyl-formamide; for 0.166667h;

4-Chloro-1,2-phenylenediamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Further stages;

Reference yield:

: 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester

: 1609575-43-0
5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

2.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

3.1: HATU / N,N-dimethyl-formamide / 0.17 h

3.2: 1 h / 20 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; HATU; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1609575-43-0
5-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}-1H-benzoimidazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.5 h

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

4.1: HATU / N,N-dimethyl-formamide / 0.17 h

4.2: 1 h / 20 °C

With ethanol; sodium tris(acetoxy)borohydride; acetic acid; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;