4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

Base Information

Chemical Name:4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid
CAS No.:1602924-01-5
Molecular Formula:C₁₇H₁₉F₆NO₂
Molecular Weight:383.334
Hs Code.:

Synonyms:4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

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Chemical Property of 4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

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Technology Process of 4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

There total 3 articles about 4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1602924-00-4
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid ethyl ester

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

Guidance literature:: With ethanol; sodium hydroxide; at 90 ℃; for 0.5h;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

1.2: 0.33 h / Inert atmosphere

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 13 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol / 0.42 h / Inert atmosphere; Reflux

With water; sodium tris(acetoxy)borohydride; acetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 13 h / 20 °C / Inert atmosphere

2: sodium hydroxide; water / ethanol / 0.42 h / Inert atmosphere; Reflux

With water; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; In ethanol; dichloromethane;