methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Base Information

Chemical Name:methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate
CAS No.:231296-93-8
Molecular Formula:C₂₁H₂₅NO₄S
Molecular Weight:387.5
Hs Code.:

Synonyms:methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

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Chemical Property of methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

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Technology Process of methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

There total 3 articles about methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 231296-92-7
(E)-methyl 3-(2-amino-5-(tert-butyl)phenyl)acrylate

: 98-59-9
p-toluenesulfonyl chloride

: 231296-93-8
methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.01.053

Reference yield:

: 103273-01-4
2-bromo-4-tert-butylaniline

: 231296-93-8
methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / acetonitrile / 9 h / Inert atmosphere; Reflux

2: pyridine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With pyridine; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In dichloromethane; acetonitrile; 1: Heck-Mizoroki cross-coupling;
DOI:10.1016/j.ejmech.2012.01.053

Reference yield:

: 769-92-6
4-tert-Butylaniline

: 231296-93-8
methyl (2E)-3-(5-tert-butyl-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / chloroform / 5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 9 h / Inert atmosphere; Reflux

3: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In dichloromethane; chloroform; acetonitrile;
DOI:10.1016/j.jfluchem.2015.07.030