methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate

Base Information

• Chemical Name: methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate
• CAS No.: 1132709-93-3
• Molecular Formula: C₁₅H₂₁ClNO₅P
• Molecular Weight: 361.762
• Mol file: 1132709-93-3.mol

Synonyms:methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate

Chemical Property of methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate

There total 2 articles about methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 3-amino-3-(diethoxyphosphoryl)propanoate (1132709-96-6) + m-Chlorobenzaldehyde (587-04-2) → methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate (1132709-93-3)

Guidance literature:

With magnesium sulfate; In dichloromethane; for 16h;

DOI:10.1002/ejoc.200800812

Reference yield: 51.0%

diethyl {[(3-chlorobenzylidene)amino]methyl}phosphonate (1132709-92-2) + bromoacetic acid methyl ester (96-32-2) → methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate (1132709-93-3)

Guidance literature:

diethyl {[(3-chlorobenzylidene)amino]methyl}phosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

bromoacetic acid methyl ester; In tetrahydrofuran; at -78 ℃;

DOI:10.1002/ejoc.200800812

Reference yield: 92.0%

methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate (1132709-93-3) + ethyl acrylate (140-88-5,9003-32-1) → diethyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)hexanedioate (1132710-00-9)

Guidance literature:

methyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)propanoate; With sodium ethanolate; In ethanol; for 0.166667h;

ethyl acrylate; In ethanol; for 2h; Reflux;

DOI:10.1002/ejoc.200800812

upstream raw materials:

diethyl {[(3-chlorobenzylidene)amino]methyl}phosphonate

bromoacetic acid methyl ester

methyl 3-amino-3-(diethoxyphosphoryl)propanoate

m-Chlorobenzaldehyde

Downstream raw materials:

dimethyl 2-{[(3-chlorobenzylidene)amino](diethoxyphosphoryl)methyl}succinate

dimethyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)pentane-1,5-dioate

diethyl 3-[(3-chlorobenzylidene)amino]-3-(diethoxyphosphoryl)hexanedioate