2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

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Chemical Name:2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran
CAS No.:1346502-45-1
Molecular Formula:C₆₂H₈₈N₄O₁₆
Molecular Weight:1145.4
Hs Code.:

2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

Synonyms:2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

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Chemical Property of 2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

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Technology Process of 2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

There total 11 articles about 2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 150196-31-9
2-(tetrahydro-2H-pyran-2-yloxy)propane-1,3-diol

: 1346502-40-6
(E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

: 1346502-45-1
2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

Guidance literature:: 2-(tetrahydro-2H-pyran-2-yloxy)propane-1,3-diol; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

(E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm2009106

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1346502-45-1
2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 0 - 20 °C

With dmap; tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 4.1: Williamson synthesis / 4.2: Williamson synthesis;
DOI:10.1021/jm2009106

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1346502-45-1
2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / 3 h / 20 °C

2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 20 °C

3.1: ammonia / methanol / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 0 - 20 °C

With ammonia; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile; 4.1: Williamson synthesis / 4.2: Williamson synthesis;
DOI:10.1021/jm2009106