2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

Base Information

Chemical Name:2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol
CAS No.:1346502-63-3
Molecular Formula:C₅₉H₈₄N₄O₁₆
Molecular Weight:1105.33
Hs Code.:

Synonyms:2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

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Chemical Property of 2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

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Technology Process of 2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

There total 12 articles about 2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1346502-57-5
2-(2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl) pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethoxy)-tetrahydro-2H-pyran

: 1346502-63-3
2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 55 ℃; for 6h;
DOI:10.1021/jm2009106

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1346502-63-3
2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 0 - 20 °C

5.1: pyridinium p-toluenesulfonate / ethanol / 3 h / 55 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

6.2: 0 - 20 °C

7.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 55 °C

With dmap; tetrabutylammomium bromide; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Williamson synthesis / 4.2: Williamson synthesis;
DOI:10.1021/jm2009106

Reference yield:

: 937183-61-4
4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

: 1346502-63-3
2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 3 h / 55 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

5.2: 0 - 20 °C

6.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 55 °C

With dmap; tetrabutylammomium bromide; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Williamson synthesis / 3.2: Williamson synthesis;
DOI:10.1021/jm2009106