ethyl hydrogen trans-cyclohexane-1,2-dicarboxylate

Base Information

• Chemical Name: ethyl hydrogen trans-cyclohexane-1,2-dicarboxylate
• CAS No.: 97718-55-3
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.235
• Mol file: 97718-55-3.mol

Synonyms:1,2-Cyclohexanedicarboxylicacid, monoethyl ester, trans-

Chemical Property of ethyl hydrogen trans-cyclohexane-1,2-dicarboxylate

Chemical Property:

• Boiling Point: 317.4°Cat760mmHg
• Flash Point: 121°C
• PSA: 63.60000
• Density: 1.158g/cm³
• LogP: 1.44050

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl hydrogen trans-cyclohexane-1,2-dicarboxylate

There total 8 articles about ethyl hydrogen trans-cyclohexane-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethanol (64-17-5) + 1,2-cis-cyclohexanedicarboxylic anhydride (13149-00-3) → (1R,2S)-Cyclohexane-1,2-dicarboxylic acid monoethyl ester (17488-76-5,67805-22-5,97718-55-3)

Guidance literature:

With boron trifluoride diethyl etherate; for 0.00833333h; further reagents;

DOI:10.1016/S0040-4020(99)00089-7

Reference yield: 85.0%

Cyclohexane-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester → 1,2,3,4,5,6-hexahydrophthalic acid monoethylester (17488-76-5,67805-22-5,97718-55-3)

Guidance literature:

With methanesulfonic acid; 1-methylimidazolium hydrobromide; at 120 ℃; for 6h;

DOI:10.14233/ajchem.2013.14947

Reference yield: 80.5%

dl-cis-ethyl methyl cyclohexane-1,2-dicarboxylate (76772-95-7) → cis-2-(ethoxycarbonyl)cyclohexanecarboxylic acid (76756-35-9,17488-76-5,67805-22-5,97718-55-3)

Guidance literature:

With aluminum tri-bromide; ethanethiol; for 48h; Ambient temperature;

DOI:10.1021/jo00323a004

upstream raw materials:

ethanol

1,2-cis-cyclohexanedicarboxylic anhydride

dl-cis-ethyl methyl cyclohexane-1,2-dicarboxylate

(1S,2R)-Cyclohexane-1,2-dicarboxylic acid monoethyl ester

Downstream raw materials:

dl-cis-ethyl methyl cyclohexane-1,2-dicarboxylate

Refernces

• 1、 Wei, Benmei,Zhang, Zhiyong,Dai, Zhiqun,Guan, Jintao. "An efficient approach for the deprotection of esters using ionic liquid as nucleophile". . p. 6404 - 6406. Retrieved 2013/07/26.
• 2、 Yue, Tai-Yuen,McLeod, Douglas D.,Albertson, Kevin B.,Beck, Steven R.,Deerberg, Joerg,Fortunak, Joseph M.,Nugent, William A.,Radesca, Lilian A.,Tang, Liya,Xiang, Cathie Dong. "Stereoselective process for a CCR3 antagonist". . p. 262 - 271. Retrieved 2012/12/22.