5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester
• CAS No.: 737796-58-6
• Molecular Formula: C₁₅H₁₉IO₅
• Molecular Weight: 406.217
• Mol file: 737796-58-6.mol

Synonyms:5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester

Chemical Property of 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester

There total 3 articles about 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-2-iodo-benzoic acid (57772-57-3) → 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester (737796-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH

With sodium hydride;

DOI:10.1002/1521-3773(20011203)40:23<4393::AID-ANIE4393>3.0.CO;2-2

Reference yield:

2-amino-5-hydroxybenzoic acid (394-31-0) → 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester (737796-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaNO₂; H₂SO₄; KI

2: NaH

With sulfuric acid; sodium hydride; potassium iodide; sodium nitrite;

DOI:10.1002/1521-3773(20011203)40:23<4393::AID-ANIE4393>3.0.CO;2-2

Reference yield:

ethyl bromoacetate (105-36-2) + tert-butyl 5-hydroxy-2-iodobenzoate (409334-78-7) → 5-ethoxycarbonylmethoxy-2-iodo-benzoic acid tert-butyl ester (737796-58-6)

Guidance literature:

With sodium hydride;

DOI:10.1002/1521-3773(20011203)40:23<4393::AID-ANIE4393>3.0.CO;2-2

upstream raw materials:

ethyl bromoacetate

tert-butyl 5-hydroxy-2-iodobenzoate

2-amino-5-hydroxybenzoic acid

5-hydroxy-2-iodo-benzoic acid