(1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde

Base Information

• Chemical Name: (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde
• CAS No.: 1013657-39-0
• Molecular Formula: C₃₂H₅₆O₃Si
• Molecular Weight: 516.88
• Mol file: 1013657-39-0.mol

Synonyms:(1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde

Chemical Property of (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde

There total 9 articles about (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H60O4Si → (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde (1013657-39-0)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 25h; Inert atmosphere;

DOI:10.1021/jo202261z

Reference yield:

C33H58O3Si → (1R,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde + (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde (1013657-39-0)

Guidance literature:

C₃₃H₅₈O₃Si; With trichloroacetic acid;

With sodium methylate;

DOI:10.1021/ol702977x

Reference yield:

(R,Z)-triisopropyl(3-(1-(2,4,6-triisopropylphenyl)ethoxy)allyloxy)silane (1030594-67-2) → (1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde (1013657-39-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: zinc/copper couple / diethyl ether / 0.5 h / 20 °C / Inert atmosphere

2.1: ammonium chloride / methanol; diethyl ether / 0.17 h / Inert atmosphere; Reflux

3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1.42 h / -35 - 20 °C / Inert atmosphere

3.2: 3.5 h / 20 °C / Reflux; Inert atmosphere

4.1: dichloromethane; water / 1 h / Inert atmosphere

5.1: sodium methylate / methanol / 25 h / 20 °C / Inert atmosphere

With zinc/copper couple; sodium methylate; potassium hexamethylsilazane; ammonium chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene;

DOI:10.1021/jo202261z

upstream raw materials:

(2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanone

(R,Z)-triisopropyl(3-(1-(2,4,6-triisopropylphenyl)ethoxy)allyloxy)silane

(R,Z)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)prop-2-en-1-ol

2-[(R)-1-((E)-1,2-dichlorovinyloxy)ethyl]-1,3,5-triisopropylbenzene

Downstream raw materials:

((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol