((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol

Base Information

• Chemical Name: ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol
• CAS No.: 1013657-40-3
• Molecular Formula: C₃₂H₅₈O₃Si
• Molecular Weight: 518.896

Synonyms:((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol

Chemical Property of ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol

There total 8 articles about ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde (1013657-39-0) → ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol (1013657-40-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; Inert atmosphere;

DOI:10.1021/jo202261z

Reference yield:

(R,Z)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)prop-2-en-1-ol (1357378-25-6) → ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol (1013657-40-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

2.1: zinc/copper couple / diethyl ether / 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium chloride / methanol; diethyl ether / 0.17 h / Inert atmosphere; Reflux

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1.42 h / -35 - 20 °C / Inert atmosphere

4.2: 3.5 h / 20 °C / Reflux; Inert atmosphere

5.1: dichloromethane; water / 1 h / Inert atmosphere

6.1: sodium methylate / methanol / 25 h / 20 °C / Inert atmosphere

7.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; zinc/copper couple; sodium methylate; potassium hexamethylsilazane; ammonium chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo202261z

Reference yield:

(2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanone (1013657-37-8) → ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol (1013657-40-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1.42 h / -35 - 20 °C / Inert atmosphere

1.2: 3.5 h / 20 °C / Reflux; Inert atmosphere

2.1: dichloromethane; water / 1 h / Inert atmosphere

3.1: sodium methylate / methanol / 25 h / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere

With sodium tetrahydroborate; sodium methylate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;

DOI:10.1021/jo202261z

upstream raw materials:

(1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanecarbaldehyde

(2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanone

(R,Z)-triisopropyl(3-(1-(2,4,6-triisopropylphenyl)ethoxy)allyloxy)silane

(R,Z)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)prop-2-en-1-ol

Downstream raw materials:

((1S,2S,3S)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)cyclobutane-1,2-diyl)dimethanol

lobucavir

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1013657-40-3 ((1S,2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutyl)methanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send