4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide
• CAS No.: 1148108-84-2
• Molecular Formula: C₁₀H₈N₄O₃S₃
• Molecular Weight: 328.397
• Mol file: 1148108-84-2.mol

Synonyms:4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide

Chemical Property of 4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

4-Isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide

There total 1 articles about 4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

thiophosgene (463-71-8) + sulfametrole (32909-92-5) → 4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide (1148108-84-2)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 1h;

DOI:10.1080/10426500802561096

Reference yield: 81.0%

4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide (1148108-84-2) + α-bromoacetophenone (70-11-1) + malononitrile (109-77-3) → 4-(4-amino-5-benzoyl-3-cyanothiophen-2-ylamino)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide (1217859-34-1)

Guidance literature:

4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide; malononitrile; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

α-bromoacetophenone; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1080/10426500802561096

Reference yield: 81.0%

4-isothiocyanato-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide (1148108-84-2) + 3,5-dichloroantranilic acid (2789-92-6) → 4-(6,8-dichloro-4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide (1148108-86-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 1h; Reflux;

DOI:10.1080/10426500801967815

upstream raw materials:

thiophosgene

sulfametrole

Downstream raw materials:

4-(3-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thioureido)-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide

4-(2-thioxo-1,2,5,6,7-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidi-4-yl)-1-benzenesulfonamide

ethyl 2-(3-(4-(N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfamoyl)phenyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

N-(4-methoxy-1,2,5-thiadiazol-3-yl)-4-(4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide

Refernces

• 1、 El-Gaby,Ismail,Abdel-Gawad,Aly,Ghorab. "Synthesis of thiazolidine and thiophene derivatives for evaluation as anticancer agents". experimental part. p. 2645 - 2654. Retrieved 2010/04/05.