1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

Base Information

Chemical Name:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone
CAS No.:181869-34-1
Molecular Formula:C₂₄H₂₁F₂N₇O₂
Molecular Weight:477.473
Hs Code.:

Synonyms:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

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Chemical Property of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

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Technology Process of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

There total 6 articles about 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 181870-52-0
1-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

: 181869-34-1
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

Guidance literature:: 1-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1.5h;

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 19h;
DOI:10.1248/cpb.48.1935

Reference yield:

: 2301-25-9
1-(4-nitrophenyl)-1H-imidazole

: 181869-34-1
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 73 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C

2.1: 98 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 82 percent / pyridine / 3 h / 50 °C

4.1: 57 percent / aq. HCl / methanol / 14 h / 20 °C

5.1: NaH / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

5.2: 24 percent / 1-methyl-pyrrolidin-2-one / 19 h / 80 °C

With pyridine; hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.48.1935

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 181869-34-1
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-imidazolyl)phenyl]-2(1H,3H)-imidazolone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / K₂CO₃ / dimethylformamide / 70 - 80 °C

2.1: 73 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C

3.1: 98 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 82 percent / pyridine / 3 h / 50 °C

5.1: 57 percent / aq. HCl / methanol / 14 h / 20 °C

6.1: NaH / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

6.2: 24 percent / 1-methyl-pyrrolidin-2-one / 19 h / 80 °C

With pyridine; hydrogenchloride; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1935