2301-25-9

Basic information

• Product Name: 1-(4-Nitrophenyl)-1H-imidazole
• Synonyms: 1-(4-NITROPHENYL)IMIDAZOLE;1-(4-NITROPHENYL)-1H-IMIDAZOLE;AKOS BBS-00001984;1-(p-nitrophenyl)-imidazol;1H-Imidazole, 1-(4-nitrophenyl)-;1-(Imidazol-1-yl)-4-nitrobenzene;1-(Imidazol-1-yl)-4-nitrobenzene, GC 97%
• CAS NO: 2301-25-9
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.17
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Imidazoles
• Mol File: 2301-25-9.mol
• Article Data: 175

Chemical Properties

• Melting Point: 198-203 °C(lit.)
• Boiling Point: 374.109 °C at 760 mmHg
• Flash Point: 180.055 °C
• Appearance: /
• Density: 1.339 g/cm³
• Vapor Pressure: 1.84E-05mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-Nitrophenyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Nitrophenyl)-1H-imidazole(2301-25-9)
• EPA Substance Registry System: 1-(4-Nitrophenyl)-1H-imidazole(2301-25-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: NI7962000
• HazardClass: IRRITANT
• Hazardous Substances Data: 2301-25-9(Hazardous Substances Data)

Usage

General Description

1-(4-Nitrophenyl)-1H-imidazole is a chemical compound with the molecular formula C9H7N3O2. It is a derivative of imidazole and contains a nitrophenyl group. 1-(4-Nitrophenyl)-1H-imidazole is commonly used in pharmaceutical and research applications, particularly as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is known for its antimicrobial and antifungal properties, and is used as a building block in the production of drugs targeting various infections. Additionally, 1-(4-Nitrophenyl)-1H-imidazole has been studied for its potential use in cancer therapy. 1-(4-Nitrophenyl)-1H-imidazole is available for purchase from chemical suppliers and should be handled and used in accordance with proper safety protocols.

InChI:InChI=1/C9H7N3O2/c13-12(14)9-3-1-8(2-4-9)11-6-5-10-7-11/h1-7H

Upstream product

• 288-32-4 1H-imidazole 
• 636-98-6 p-nitrobenzene iodide 
• 100-00-5 4-chlorobenzonitrile 
• 586-78-7 para-nitrophenyl bromide 
• 50-00-0 formaldehyd 
• 131543-46-9 Glyoxal 
• 100-01-6 4-nitro-aniline 
• 24067-17-2 4-nitrophenylboronic acid 
• 100-25-4 para-dinitrobenzene 
• 1142-27-4 p-nitrophenyl N,N-dimethylsulphamate 
• 3848-45-1 4-nitrophenyl N,N-diethylcarbamate 
• 100-02-7 4-nitro-phenol 
• 288-13-1 NH-pyrazole 
• 5587-42-8 imidazolyl sodium 

Downstream Products

• 100-17-4 para-methoxynitrobenzene 
• 2221-00-3 4-(N-imidazolyl)aniline 
• 100-29-8 1-ethoxy-4-nitrobenzene 
• 131885-65-9 5-(1H-imidazol-1-yl)-2-nitroaniline 
• 919281-63-3 Br^(1-)*C₁₈H₁₆N₃O₄⁽¹⁺⁾ 
• 1235868-97-9 [(η4-1,5-cyclooctadiene)RhCl(1-(4-nitrophenyl)imidazole)] 
• 1235868-93-5 [(η3:η3-C10H16)RuCl2(1-(4-nitrophenyl)imidazole)] 
• 1283084-93-4 dichlorobis(1-(4-nitrophenyl)imidazole-κN3)nickel(II) 
• 1283085-02-8 dichlorobis(1-(4-nitrophenyl)imidazole-κN3)zinc 
• 1283084-90-1 dichlorobis(1-(4-nitrophenyl)imidazole-κN3)cobalt(II) 
• 1283084-97-8 dichlorobis(1-(4-nitrophenyl)imidazole-κN3)copper(II) 
• 56643-85-7 4-(1-imidazolylmethyl)aniline 

Relevant articles and documents

CuI catalyzed C-N bond forming reactions between aryl/heteroaryl bromides and imidazoles in [Bmim]BF4

By using CuI as the catalyst and l-Proline as the ligand, the Ullmann-type coupling reactions of aryl/heteroaryl bromides and imidazoles in [Bmim]BF4 at 105-115 °C gave the corresponding N-arylimidazoles/N-heteroarylimidazoles in good yields. T

Functionalization of superparamagnetic Fe3O4@SiO2 nanoparticles with a Cu(II) binuclear Schiff base complex as an efficient and reusable nanomagnetic catalyst for N-arylation of α-amino acids and nitrogen-containing heterocycles with aryl halides

Fe3O4@SiO2 nanoparticles was functionalized with a binuclear Schiff base Cu(II)-complex (Fe3O4@SiO2/Schiff base-Cu(II) NPs) and used as an effective magnetic hetereogeneous nanocatalyst for the N-arylation of α-amino acids and nitrogen-containig heterocycles. The catalyst, Fe3O4@SiO2/Schiff base-Cu(II) NPs, was characterized by Fourier transform infrared (FTIR) and ultraviolet-visible (UV-vis) analyses step by step. Size, morphology, and size distribution of the nanocatalyst were studied by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and dynamic light scatterings (DLS) analyses, respectively. The structure of Fe3O4 nanoparticles was checked by X-ray diffraction (XRD) technique. Furthermore, the magnetic properties of the nanocatalyst were investigated by vibrating sample magnetometer (VSM) analysis. Loading content as well as leaching amounts of copper supported by the catalyst was measured by inductive coupled plasma (ICP) analysis. Also, thermal studies of the nanocatalyst was studied by thermal gravimetric analysis (TGA) instrument. X-ray photoelectron spectroscopy (XPS) analysis of the catalyst revealed that the copper sites are in +2 oxidation state. The Fe3O4@SiO2/Schiff base-Cu(II) complex was found to be an effective catalyst for C–N cross-coupling reactions, which high to excellent yields were achieved for α-amino acids as well as N-hetereocyclic compounds. Easy recoverability of the catalyst by an external magnet, reusability up to eight runs without significant loss of activity, and its well stability during the reaction are among the other highlights of this catalyst.

L-Proline N-oxide dihydrazides as an efficient ligand for cross-coupling reactions of aryl iodides and bromides with amines and phenols

A novel catalytic system based on L-proline N-oxide/CuI was developed and applied to the cross-coupling reactions of various N- and O- nucleophilic reagents with aryl iodides and bromides. This strategy featured in the employment of an-proline derived dihydrazides N-oxide compound as the superior supporting ligand. By using this protocol, a variety of products, including N-arylimidazoles, N-arylpyrazoles, N-arylpyrroles, N-arylamines, and aryl ethers, were synthesized with up to 99% yield.

Fe-MIL-101 modified by isatin-Schiff-base-Co: a heterogeneous catalyst for C-C, C-O, C-N, and C-P cross coupling reactions

A metal-organic framework functionalized with a cobalt-complex is preparedviapost-synthetic modification of Fe-MIL-101-NH2. Initially, Fe-MIL-101-NH2reacted with isatin to produce Fe-MIL-101-isatin-Schiff-base, which can anchor the cobalt by the addition of cobalt acetate. The resulting MOF-Co catalyst is characterized by employing multiple techniques. This new modified MOF acts as a heterogeneous and recyclable catalyst for efficient Ullmann, Buchwald-Hartwig, Hirao, Hiyama and Mizoroki-Heck cross-coupling reactions of several aryl halides/phenylboronic acid/phenyltosylate with phenols, anilines/heterocyclic amines, triethyl phosphite, triethoxyphenylsilane and alkenes and generates the expected coupling products in good to high yields.