ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Base Information

Chemical Name:ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate
CAS No.:1544739-68-5
Molecular Formula:C₃₃H₃₅F₂NO₅
Molecular Weight:563.641
Hs Code.:

ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Synonyms:ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

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Chemical Property of ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

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Technology Process of ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

There total 17 articles about ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1544739-65-2
4-((4-bromo-3,5-dimethylphenoxy)methyl)-4-fluorotetrahydro-2H-pyran

: 1544739-24-3
4-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester

: 1544739-68-5
ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; for 1h; Reflux;

Reference yield:

: 1544739-10-7
(4-bromo-5-vinyl-pyridin-2-yl)-bis-(4-methoxy-benzyl)-amine

: 1544739-68-5
ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 18.33 h / Reflux; Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / Reflux; Inert atmosphere

3.1: rhodium(II) acetate / dichloromethane / 0.25 h

3.2: 3 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: sulfuric acid; sodium nitrite / 2 h / 0 - 20 °C

6.1: silver carbonate / toluene / 110 °C / Inert atmosphere

7.1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / water; 1,4-dioxane / 1 h / Reflux

With rhodium(II) acetate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; potassium carbonate; caesium carbonate; silver carbonate; trifluoroacetic acid; sodium nitrite; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 1544739-62-9
4-((ethylperoxy)methyl)-4-fluorotetrahydro-2H-pyran

: 1544739-68-5
ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; sodium tetrahydroborate / 3 h / 0 - 20 °C

2: pyridine / 1 h / 0 - 20 °C

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 3 h / 20 °C

4: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / water; 1,4-dioxane / 1 h / Reflux

With pyridine; methanol; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;