1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate
CAS No.:1307272-73-6
Molecular Formula:C₂₆H₃₁Cl₂N₅O₄S₂
Molecular Weight:612.601
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

There total 5 articles about 1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 1307272-36-1
N-(2-chloro-3-(2-(2-chloropyrimidin-4-yl)acetyl)phenyl)propane-1-sulfonamide

: 1307272-73-6
1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Guidance literature:: N-(2-chloro-3-(2-(2-chloropyrimidin-4-yl)acetyl)phenyl)propane-1-sulfonamide; With N-Bromosuccinimide; In ISOPROPYLAMIDE; at 20 ℃; for 1.33333h; Inert atmosphere;

tert-butyl 4-carbamothioylpiperidine-1-carboxylate; In ISOPROPYLAMIDE; at 20 ℃; for 72h; Inert atmosphere;

Reference yield:

: 120100-15-4
methyl 3-amino-2-chlorobenzoate

: 1307272-73-6
1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

2.2: -10 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1.33 h / 20 °C / Inert atmosphere

3.2: 72 h / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE;

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 1307272-73-6
1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / methanol / 3.5 h / 25 °C / 2585.81 Torr / Inert atmosphere

2.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

3.2: -10 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1.33 h / 20 °C / Inert atmosphere

4.2: 72 h / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ISOPROPYLAMIDE;